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England head coach Stuart Lancaster has handed debuts to Luther Burrell and Jack Nowell for the Six Nations opener against France in Paris on Saturday.
Exeter Chiefs winger Nowell is preferred to Chris Ashton, while Northampton Saints star Burrell will start in the centre alongside Billy Twelvetrees, with Gloucester's Jonny January winning just his second cap on the opposite wing to Nowell.
Danny Care earns a start at scrum-half,as Lancaster makes four changes to the XV who started the 30-22 defeat to New Zealand in January.
And captain Chris Robshaw has challenged his side to put on a big show in Paris on Saturday, with England desperate to get off to a winning start.
He said: "To be successful you have to go to places like the Stade France - a tough environment with a hostile crowd - in a first-up encounter and hit the ground running.
"A win would be massive. It would get us off to the best possible start."
England can be backed at2.37to win in Paris on Saturday, with the visitors2.00to open the scoring and2.62to do so with a penalty.
France, meanwhile, have opted to hand a debut to Stade Francais fly-half Jules Plisson against England, with Pascal Pape captaining Les Bleus in the absence of the injured Thierry Dusautoir.
England:Brown (Harlequins), Nowell (Exeter Chiefs), Burrell (Northampton Saints), Twelvetrees (Gloucester), January (Gloucester), Farrell (Saracens), Care (Harlequins); Marler (Harlequins), Hartley (Northampton Saints), Cole (Leicester Tigers), Launchbury (London Wasps), Lawes (Northampton Saints), Wood (Northampton Saints), Robshaw (Harlequins, capt), B Vunipola (Saracens).
Replacements:T Youngs (Leicester Tigers), M Vunipola (Saracens), Thomas (Sale Sharks), Attwood (Bath), Morgan (Gloucester), Dickson (Northampton Saints), Barritt (Saracens), Goode (Saracens).
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